ECM controls flow-induced NF-κB
نویسندگان
چکیده
منابع مشابه
ECM controls flow-induced NF-κB
he spindle checkpoint blocks exit from mitosis until all kinetochores are bound by spindle micro-tubules. At that point, Cdc20 is released by the checkpoint proteins and activates the anaphase promoting complex (APC), a ubiquitin ligase, to initiate anaphase. On page 61, Casaletto et al. identify Xnf7 as the first APC regulator known to bind the core APC components, rather than Cdc20. On page 4...
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Atherosclerotic plaque forms in regions of the vasculature exposed to disturbed flow. NF-kappaB activation by fluid flow, leading to expression of target genes such as E-selectin, ICAM-1, and VCAM-1, may regulate early monocyte recruitment and fatty streak formation. Flow-induced NF-kappaB activation is downstream of conformational activation of integrins, resulting in new integrin binding to t...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1691iti2